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KMID : 0379120010290010061
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Korean Journal of Mycology
2001 Volume.29 No. 1 p.61 ~ p.66
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In vitro Antitumor Activity of Ergosterol Peroxide Isolated from Cordyceps militaris on Cancer Cell Lines from Korean Patients
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Kim Young-Ho
Lee Sung-Jin
Kim Ha-Won
Hyun Jin-Won
Lee Seung-Jung
Jeong Eun-Ho
Cai Xing-Fu
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Abstract
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Entomopathogenic fungus of Cordyceps militaris is famous of its medicinal efficacies. An antitumor compound was purified from the n-hexane extract of artificially cultivated fruiting bodies of C. militaris and identified as ergosterol peroxide (5α,8α-epidioxy-24(R)-methylcholesta-6,22-dien-3β-ol, C_(28)H_(44)O₃) mainly by ¹H and ^(13)C-NMR spectroscopic techniques. When the antitumor activity of ergosterol peroadde was measured against 3 tumor cell lines from Korean cancer patients, it showed the most strong activity against gastric cancer SNU-1 cell line 3 days after treatment. The 50% inhibitory concentrations (IC_(50)) of ergosterol peroxide 6 days after treatment were 75.8 ㎍/㎖ for human gastric SNU-1 tumor cell line, 39.7 ㎍/㎖ for human colorectal SNU-C4 tumor cell line and 32.7 ㎍/㎖ for human hepatoma SNU-354 cell line.
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